Glaucoma Clinical Trials Launched in 2025: A Complete Overview
New Eye Drops and Supplements: Beyond GLP-1 drugs, other novel compounds are under study. For example, Ocular Neuroenhancement: Early trials of...
Deep research and expert guides on maintaining your visual health.
New Eye Drops and Supplements: Beyond GLP-1 drugs, other novel compounds are under study. For example, Ocular Neuroenhancement: Early trials of...
Pyruvate is a three-carbon compound our bodies make when sugars are broken down for energy (). Think of it as a key fuel molecule: it can enter cells...
A recent review reminds us that after decades of work, “only a handful of neuroprotective therapies have succeeded clinically” (). In other words,...
Several clinical trials have tested whether oral PEA can help lower IOP in glaucoma or ocular hypertension. In these studies, patients usually...
Likewise, general ROCK inhibition (with other agents like Y-27632) can encourage neurite extension when growth factors are present (). In an adult...
In simple terms: because glaucoma hurts the very cells that tell our body when to wake and sleep, a vicious cycle can start where bad sleep and...
Gene therapies are also under study to deliver neurotrophic signals. One innovative approach engineered a permanently active version of the BDNF...
In the next few years, the emphasis will be on neuroprotection/neuroenhancement – therapies that aim to preserve or slightly improve the function of...
RGCs have extremely high metabolic demands and rely on robust mitochondrial function. In glaucoma, aging and chronic stress trigger progressive NAD+...
Experimental work suggests several ways brief currents can boost neural survival and plasticity. One class of effects is neurotrophic upregulation:...
Taurine plays key cellular roles beyond being a nutrient. In the retina it acts as an organic osmolyte, helping cells adjust their volume under...
By inducing autophagy, spermidine helps cells clear damaged components and maintain mitochondrial health. For example, chronic spermidine feeding in...
In the eye, microglia (resident immune cells) amplify inflammation when activated. Curcumin dampens microglial over-activation and cytokine release....
Citicoline (cytidine-5′-diphosphocholine) is metabolized into cytidine and choline in the body. Choline feeds into the synthesis of...
Alpha-lipoic acid (ALA), also known as thioctic acid, is a short-chain sulfur-containing fatty acid synthesized in mitochondria. In its reduced form...
Importantly, this system exists not only in muscle but in nerve cells. Neurons (including RGCs) express CK isoforms that enable them to use creatine....
However, combining many compounds also has pitfalls. Overlapping mechanisms can lead to diminishing returns. The so-called “antioxidant paradox”...
By contrast, larger reviews find no clear benefit on field metrics. A 2025 systematic review of 8 trials (428 subjects) concluded that GBE did not...
Neuroprotection refers to strategies and treatments meant to protect nerve cells from damage, slow their degeneration, or help them recover after injury. In the context of the eye, it means trying to keep retinal ganglion cells and the optic nerve healthy so vision is preserved even when other risk factors, like eye pressure, are present. Approaches to neuroprotection include drugs that reduce harmful chemical reactions, improve energy production in cells, reduce inflammation, or boost blood flow and oxygen delivery to nerve tissue. Lifestyle measures, such as good cardiovascular health, healthy diet, and avoiding smoking, also support nerve health. Scientists are testing many ideas for neuroprotection, from medications and nutritional supplements to devices and gene therapies, but evidence varies and research is ongoing. Neuroprotection matters because once nerve cells are lost, they do not regrow easily, so preventing damage is often the best way to preserve function. In conditions where standard treatments do not fully stop progression, adding neuroprotective strategies could help maintain vision or slow decline. Discussing neuroprotection with a healthcare provider can help people understand realistic expectations and available options for protecting nerve health.