retinal ganglion cells

Deep research and expert guides on maintaining your visual health.

Gene Therapy for Optic Nerve Regeneration: Modulating PTEN/mTOR, KLFs, and Sox11

Gene Therapy for Optic Nerve Regeneration: Modulating PTEN/mTOR, KLFs, and Sox11

Introduction Vision loss from optic nerve injury or glaucoma happens because retinal ganglion cells (RGCs) fail to regrow their axons. In adult mammals, the intrinsic growth program of RGCs is normally shut off, so damaged nerves do not heal o...

Taurine and Retinal Ganglion Cell Survival Across the Lifespan

Taurine and Retinal Ganglion Cell Survival Across the Lifespan

Introduction Taurine is a nutrient-rich amino sulfonic acid found in high concentrations in the retina and other neural tissues. In fact, taurine levels in the retina are higher than in any other body tissue, and its depletion causes retinal ...

Green Tea Catechins (EGCG) for Neurovascular Health in Glaucoma and Aging

Green Tea Catechins (EGCG) for Neurovascular Health in Glaucoma and Aging

EGCG and Neurovascular Health in Glaucoma and Aging Green tea cultures have long prized their tea’s catechins—particularly epigallocatechin-3-gallate (EGCG)—for promoting health. Modern research suggests EGCG’s potent antioxidant, anti...

Resveratrol and Sirtuin Pathways: From Trabecular Meshwork to Longevity

Resveratrol and Sirtuin Pathways: From Trabecular Meshwork to Longevity

Resveratrol’s Promise in Glaucoma: Ocular Cells and Systemic Aging Resveratrol is a polyphenolic compound often touted as a “caloric restriction mimetic” and SIRT1 activator with antioxidant and anti-inflammatory effects. Early studies sh...

Spermidine and Autophagy: A Longevity Nutrient for the Aging Eye

Spermidine and Autophagy: A Longevity Nutrient for the Aging Eye

Spermidine: An Autophagy-Inducing Polyamine for Eye Health Spermidine is a naturally occurring polyamine found in all cells and in many aging-friendly foods. It has recently attracted attention as an autophagy inducer and “longevity” nutr...

Citicoline (CDP-Choline) for Visual Pathway Support and Cognitive Aging

Citicoline (CDP-Choline) for Visual Pathway Support and Cognitive Aging

Introduction Citicoline, also known as CDP-choline, is a naturally occurring compound that supports nerve cell function. It serves as a key precursor for phospholipids — essential components of cell membranes — and boosts levels of importa...

Alpha-Lipoic Acid: Redox Modulation and Neurovascular Support in Glaucoma

Alpha-Lipoic Acid: Redox Modulation and Neurovascular Support in Glaucoma

Alpha-Lipoic Acid in Glaucoma: A Neurovascular Antioxidant Strategy Glaucoma is a progressive optic neuropathy in which elevated intraocular pressure, vascular insufficiency, and oxidative stress contribute to retinal ganglion cell (RGC) d...

Creatine and Energy Buffering in Retinal and Optic Nerve Tissues

Creatine and Energy Buffering in Retinal and Optic Nerve Tissues

Introduction Retinal ganglion cells (RGCs) are the neurons that send visual signals from the eye to the brain. They rely on a high-energy metabolism because they must maintain electrical signals over long distances. In glaucoma and related opti...

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