Mthfr

MTHFR

MTHFR stands for methylenetetrahydrofolate reductase, which is a gene that provides instructions for making an enzyme important in processing folate (a form of vitamin B9) and regulating levels of a compound called homocysteine. The enzyme helps convert folate into a form the body can use to make building blocks for DNA and to support the chemical reactions that recycle homocysteine into useful molecules. Variations in this gene can reduce how well the enzyme works, which in some people leads to higher homocysteine levels or changes in folate metabolism. Having a common variation is relatively frequent and does not automatically mean someone will become ill, but it can be one factor among many that affects health. Elevated homocysteine has been linked to a higher risk of some cardiovascular and pregnancy-related issues, though the relationship is complex and influenced by diet and other genes. Because the enzyme interacts closely with B vitamins, checking and adjusting intake of folate, B12, and B6 can often help manage related metabolic effects. Testing for the gene variant is available, but results should be interpreted with a healthcare professional who can consider the whole clinical picture. Lifestyle and dietary choices usually play a large role in whether a genetic difference leads to problems. Understanding MTHFR matters because it connects genetics, nutrition, and disease risk in ways that can often be managed with information and simple interventions.