Gene Therapy for Optic Nerve Regeneration: Modulating PTEN/mTOR, KLFs, and Sox11
Introduction Vision loss from optic nerve injury or glaucoma happens because retinal ganglion cells (RGCs) fail to regrow their axons. In adult mammal...
Sox11
Deep research and expert guides on maintaining your visual health.
Sox11
Sox11 is a protein that helps control which genes are turned on or off inside cells. It belongs to a family of proteins called transcription factors that act like switches during development. Sox11 is especially active when nerve cells are forming and when tissues are repairing themselves after injury. By changing levels of Sox11, cells can be nudged to grow, change shape, or form connections with other cells. Scientists study Sox11 because it influences how neurons mature and extend long fibers called axons. In experiments, increasing or decreasing Sox11 can speed up or slow down nerve growth, showing it has a strong effect on repair processes. That makes it interesting for developing treatments that aim to encourage damaged nerves to regrow. However, Sox11 does not act alone and its effects depend on many other genes and signals, so changing it can have unintended consequences. For example, too much or poorly timed Sox11 activity could interfere with normal cell function or cause misguided growth. Understanding how Sox11 works helps researchers design safer, more precise ways to support healing and restore function after injury.