Senolytics

senolytics

Senolytics are a type of experimental treatment that aim to remove senescent cells from the body. Senescent cells are cells that have stopped dividing but remain alive and often secrete inflammatory and tissue-damaging molecules. While senescence can be helpful in wound healing or cancer suppression, these cells tend to build up as we age and in certain diseases, contributing to chronic inflammation and tissue decline. Senolytic agents selectively target and eliminate these problematic cells so that tissues can repair and function more normally. In animal studies, clearing senescent cells has improved mobility, organ function, and some features of aging, which has generated excitement about possible human benefits. Research in people is still early, so the safety, best dosing, and long-term effects are under active study. Because these treatments change how cells survive, they can have side effects and may interact with other conditions or medicines, so careful testing is essential. If successful, senolytic therapies could become tools to treat age-related diseases and improve quality of life rather than simply treating symptoms. For now, they represent a promising area of research that may change how we think about aging and chronic disease in the future.