Collagen Peptides and the Trabecular Meshwork: Mechanistic Links to Intraocular Pressure
In a healthy eye, the TM and SC work together like a plumbing system. The TM is a spongy, porous tissue lined by endothelial cells, and it sits just...
Mmp
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MMP
MMP stands for matrix metalloproteinase, a family of enzymes that break down proteins in the extracellular matrix, the scaffold that surrounds cells. These enzymes need metal ions, usually zinc, to work and they cut components like collagen and elastin into smaller pieces. By trimming or removing structural proteins, MMPs help remodel tissues during normal processes such as growth, wound healing, and development. They also allow cells to move through tissues, which is important for immune responses and tissue repair. If MMP activity is too high, it can lead to tissue damage and contribute to diseases like arthritis, chronic wounds, and cancer spread. If their activity is too low, tissues can become overly stiff or scarred because old matrix is not removed efficiently. The body controls MMPs with natural inhibitors to keep a balance, and researchers study this balance to understand many diseases. MMPs are used as biomarkers to monitor tissue remodeling and are potential targets for drugs aimed at preventing destructive tissue breakdown.