Gentherapi til regeneration af synsnerven: Modulering af PTEN/mTOR, KLFs og Sox11
Introduktion Synstab som følge af skade på synsnerven eller glaukom opstår, fordi retinale ganglieceller (RGC'er) ikke formår at genudvikle deres akso...
시각 건강을 유지하기 위한 심층 연구 및 전문가 가이드.
Introduktion Synstab som følge af skade på synsnerven eller glaukom opstår, fordi retinale ganglieceller (RGC'er) ikke formår at genudvikle deres akso...
Вступ Втрата зору внаслідок пошкодження зорового нерва або глаукоми відбувається через неспроможність гангліозних клітин сітківки (ГКС) відновити свої...
引言 视神经损伤或青光眼导致的视力丧失,是因为视网膜神经节细胞 (RGCs) 无法重新生长其轴突。在成年哺乳动物中,RGCs 的内源性生长程序通常处于关闭状态,因此受损的神经无法自行愈合 (pmc.ncbi.nlm.nih.gov)。最近的小鼠研究表明,基因疗法可以重新激活这些生长通路。例如,在成年...
Introduction La perte de vision due à une lésion du nerf optique ou au glaucome survient parce que les cellules ganglionnaires de la rétine (CGR) ne p...
Introducere Pierderea vederii cauzată de leziuni ale nervului optic sau glaucom apare deoarece celulele ganglionare retiniene (CGR) nu reușesc să-și r...
はじめに 視神経損傷や緑内障による視力喪失は、網膜神経節細胞(RGC)が軸索を再成長させられないために起こります。成体哺乳類では、RGCの内在性成長プログラムは通常停止しており、損傷した神経は自然には治癒しません (pmc.ncbi.nlm.nih.gov)。最近のマウス研究では、遺伝子治療によって...
Giriş Optik sinir yaralanması veya glokomdan kaynaklanan görme kaybı, retinal ganglion hücrelerinin (RGC'ler) aksonlarını yeniden büyütememesinden kay...
Introduction Vision loss from optic nerve injury or glaucoma happens because retinal ganglion cells (RGCs) fail to regrow their axons. In adult mammal...
Sox11 is a protein that helps control which genes are turned on or off inside cells. It belongs to a family of proteins called transcription factors that act like switches during development. Sox11 is especially active when nerve cells are forming and when tissues are repairing themselves after injury. By changing levels of Sox11, cells can be nudged to grow, change shape, or form connections with other cells. Scientists study Sox11 because it influences how neurons mature and extend long fibers called axons. In experiments, increasing or decreasing Sox11 can speed up or slow down nerve growth, showing it has a strong effect on repair processes. That makes it interesting for developing treatments that aim to encourage damaged nerves to regrow. However, Sox11 does not act alone and its effects depend on many other genes and signals, so changing it can have unintended consequences. For example, too much or poorly timed Sox11 activity could interfere with normal cell function or cause misguided growth. Understanding how Sox11 works helps researchers design safer, more precise ways to support healing and restore function after injury.