Inflammaging

inflammaging

Inflammaging refers to the gradual, long-term increase in low-level inflammation that occurs as people get older. It is not the sudden swelling or pain of an infection, but a persistent simmer of immune system activity that can damage tissues over time. This chronic inflammation happens because the immune system changes with age, cells that no longer divide build up and release inflammatory signals, and the body becomes less efficient at clearing damaged molecules. Oxidative stress, where harmful molecules accumulate and harm cells, often goes hand in hand with this process and makes the inflammation worse. Inflammaging matters because it helps drive many common age-related problems, from heart disease and diabetes to conditions that affect the eyes and brain. Over time, the constant low-level inflammation can weaken tissues and reduce their ability to repair themselves, speeding up decline in function. Understanding inflammaging also points to ways to reduce its impact, such as through diet, exercise, medications, or supplements that calm inflammation or boost antioxidant defenses. Researchers are exploring therapies that remove senescent cells, support healthy immune responses, or lower oxidative damage to slow this process. Paying attention to lifestyle factors and medical care that lower chronic inflammation can help preserve health and quality of life as people age.