Palmitoylethanolamide

palmitoylethanolamide

Palmitoylethanolamide is a naturally occurring fatty molecule found in many tissues of the body. It acts like a signaling compound that helps control inflammation and the way nerves respond to pain. Scientists classify it as an endocannabinoid-like substance, because it works in some of the same biological pathways as compounds related to the endocannabinoid system. One key action is activating PPAR-alpha, a receptor that helps dial down inflammation and stabilize cell responses. Because of these effects, palmitoylethanolamide has been explored as a treatment to reduce chronic pain and protect nerve cells from damage. It is available in supplement form and is generally considered well tolerated, with fewer side effects than many strong pain medications. Researchers are studying it for conditions ranging from nerve pain to inflammatory diseases and even some eye and neurological concerns. While promising, evidence varies by condition, so people should talk to a healthcare professional before using it, especially if they take other medicines. Understanding palmitoylethanolamide helps people see how the body naturally controls pain and inflammation and why some natural compounds can support medical care.